Missing essential plugin:
org.jetbrains.android
Please reinstall Android Studio from scratch.
Here how I fix it in my case, Android Studio 4.2.1 on Windows 10:
Search and delete
"C:\Users\user\AppData\Roaming\Google\AndroidStudio4.X\disabled_plugins.txt"
There are two in my setup:
"C:\Users\user\AppData\Roaming\Google\AndroidStudio4.1\disabled_plugins.txt"
"C:\Users\user\AppData\Roaming\Google\AndroidStudio4.2\disabled_plugins.txt"
I delete both disabled_plugins.txt and re-start Android Studio.